The last meeting between the sides at Fenway Park saw Roma win 2-1 in 2012 and but Liverpool's quest to prevent a repeat suffered an early blow as a heavy fall from Fabio Borini, saw the Italian striker go off injured with Emre Can coming on in his place after only 12 minutes.
Liverpool had the best chance to open the scoring when Coutinho aimed a dangerous free kick at goal which just crept past the far post but Roma responded and went even closer to breaking the deadlock with a chance from Totti that went the wrong side of the post.
Roma threatened again in the 33rd minute as a cross from former Chelsea defender Ashley Cole found Totti in the box but again the Italian's shot failed to test Jones in the Liverpool goal and Liverpool responded as Coutinho looked to test Skorpski in he Roma goal but failed to hit the target meaning the sides went into the interval still level.
Coutinho looked to be the main threat for Liverpool as hit for goal again in the 48th minute but the target seemed to escape his shot but strike partner, Lambert came close to scoring his first goal for the club with a powerful shot that was denied by a strong Roma clearance before he forced Skorupski into a superb save with a clever shot just before the hour mark.
An array of changes for both sides took place on the hour mark and it was one of Liverpool's in the form of Peterson that came close to an instant impact as the Swedish attacker sent a dangerous cross into the area which found Coutinho who sent a drive towards goal only to see it denied by the Roma defence.
Roma responded to the pressure well and looked to threaten with a free-kick in the 70th minute only for Paredes to sent the chance over the bar and with just two minutes remaining , Sanabria send a powerful shot at Jones but the Australian denied the chance with a low save.
The final seconds ticked down as the sides looked to be going into special deciding penalty shoot out but Roma had other ideas as from a dangerous corner, Borriello hit a shot towards goal that saw a deflection off Agger which went past Jones and opened the scoring and with the final whistle following, Roma held on for the win.