Rodgers fielded an unchanged eleven from Sunday but found his side behind as early as the 7th minute after Gareth Bale thundered down the left side leaving Gerrard, Glen Johnson and Joe Allen all trailing behind him before sliding a perfect cross to the unmarked Aaron Lennon who tapped in at the back post.
Liverpool pushed for the equaliser and Suarez tested Lloris in the Spurs goal from the edge of the area but saw his shot saved and within minutes, Liverpool should have been level as Henderson found himself with an open goal to shoot at but from 20 yards out he missed the target after pressure from Walker.
Henderson's miss proved costly as Spurs increased their lead in the 16th minute with another moment of sheer skill by Bale as he glided in a superb free kick which looked to deflect off the wall and leave Reina with no chance of keeping it out.
Liverpool now had a massive task to keep their unbeaten run intact and were denied what looked to be a stonewall penalty as Sandro shoved Gerrard to the ground with the ball rolling to Suarez who had his shot cleared off the line to leave Liverpool still two goals down when they had two great chances in a single attack and the scoreline stayed that way into the break.
In the second half, Liverpool pushed to get back into the game but a series of chances failed to bear fruit and Rodgers brought on Shelvey for Henderson and the substitute had an influence in Liverpool pulling a goal back in the 72nd minute.
He took the corner which was kept in play by Agger and then Gerrard who hit for goal but the resulting clearance from Lennon ricocheted of Bale's face to fly into the net and leave Bale flat out on the ground after the impact.
Suarez came close to an equaliser with a well taken volley which crept just over the bar after an overhead kick cross by Agger but left Liverpool leaving North London with a loss and with the eight game unbeaten run in tatters.